Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations.
HYPIEND addresses the environmental challenge of exposure to endocrine-disrupting chemicals (EDCs) during critical developmental stages. The project aims to understand how simultaneous exposure to multiple EDCs affects the hypothalamus-pituitary (HP) axis and to develop strategies for minimizing exposure and mitigating consequences during perinatal and pre-pubertal stages. The HYPIEND project will identify EDC co-exposure patterns using computational toxicology and evaluate them through various models, including cell-based screenings and organoid-based organ-on-chip models. The project will also assess the impact of EDCs on epigenetic programming and explore non-invasive biomarkers of HP axis disruption. The knowledge gained will inform intervention studies to reduce EDC exposure in children, ultimately providing innovative methodologies and strategies for sensitive populations.
European Commission (Call: HORIZON-HLTH-2023-ENVHLTH-02).