Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations.

 Description

HYPIEND addresses the environmental challenge of exposure to endocrine-disrupting chemicals (EDCs) during critical developmental stages. The project aims to understand how simultaneous exposure to multiple EDCs affects the hypothalamus-pituitary (HP) axis and to develop strategies for minimizing exposure and mitigating consequences during perinatal and pre-pubertal stages. The HYPIEND project will identify EDC co-exposure patterns using computational toxicology and evaluate them through various models, including cell-based screenings and organoid-based organ-on-chip models. The project will also assess the impact of EDCs on epigenetic programming and explore non-invasive biomarkers of HP axis disruption. The knowledge gained will inform intervention studies to reduce EDC exposure in children, ultimately providing innovative methodologies and strategies for sensitive populations.

Period

2024-2029

Financing entities

European Commission (Call: HORIZON-HLTH-2023-ENVHLTH-02).